ABSTRACT
Objective :To explore influence of different doses of atorvastatin short‐term treatment on serum levels of adiponectin (APN) ,hsCRP ,thrombolytic granule membrane protein (GMP‐140) ,blood lipid metabolism and cardi‐ac function in patients with coronary heart disease (CHD) complicated type 2 diabetes mellitus (T2DM).Methods :A total of 108 CHD + T2DM patients treated in our hospital from May 2016 to May 2017 were randomly and equal‐ly divided into atorvastatin small dose group (10mg／d) and large dose group (40mg／d) ,each group received routine treatment simultaneously for 12 weeks .Levels of fasting plasma glucose (FPG) ,fasting insulin (FINS) ,homeostasis model‐insulin resistance index (HOMA‐IR) ,serum levels of APN ,GMP‐140 ,hsCRP etc .were measured and com‐pared between two groups before and after treatment .Results :Compared with small dose group after treatment , there were significant reductions in levels of FINS [ (7.83 ± 1.25) μIU／ml vs .(6. 95 ± 1.06) μIU／ml] ,HOMA‐IR [ (2.15 ± 0.68) vs.(1. 78 ± 0.55)] ,serum GMP‐140 [ (17. 24 ± 5.63) μg／L vs.(13. 35 ± 4.29) μg／L] ,hsCRP [ (4.83 ± 1.59) mg／L vs.(3. 56 ± 1. 17) mg／L] ,TC [ (4.83 ± 0.72) mmol／L vs.(4.11 ± 0.63) mmol／L] ,TG [ (1. 75 ± 0.46) mmol／L vs.(1.38 ± 0.35) mmol／L] ,LDL‐C [ (2.95 ± 0. 57) mmol／L vs.(2.47 ± 0.45) mmol／L] and LVEDd [ (46. 05 ± 6. 13) mm vs.(41. 59 ± 5. 28) mm] ,and significant rise in serum APN level [ (6. 40 ± 1.08) mg／L vs.(7. 22 ± 1.35) mg／L] ,LVEF [ (48.35 ± 6.08)% vs.(52.69 ± 7.53)%] and E／A [ (0. 93 ± 0. 16) vs.(1. 02 ± 0.19)] in large dose group , P＜0.01 all.Conclusion :Short‐term atorvastatin treatment can significantly improve HOMA‐IR and cardiac function ,regulate levels of blood lipid ,APN ,GMP‐140 and inflammatory factors in CHD + T2DM patients ,and it′s dose‐dependent .
ABSTRACT
A rapid detection method for dyeing wastewater by snapshot imaging spectrometer was developed. The simulated dyeing wastewater solution of a single component and mixed components was prepared and the experimental conditions were optimized. The white LED array was used as the detection light source and the image of the sample was collected by the imaging spectrometer developed in the laboratory to obtain the spectral information of the sample in the range of 400-800 nm. The standard curve between the absorbance and the concentration of the samples was established. The linear range of a single component of Rhodamine B or Orange G was 1-50 mg / L, the linear correlation coefficients was more than 0. 99, the recoveries were 93% -114% and the relative standard deviations ( RSD) were 7. 5% and 1. 3% . The correlation coefficients between predicted concentration and reference concentration reached 0. 999 in the detection of mixed component by using the multiple linear regression model, and the relative errors of 3 predicted samples were reduced. The rapid, accurate and precise method showed an excellent promise for on-site and emergency detection of dyeing wastewater.
ABSTRACT
Chemotaxis is the response ability of motile cells to chemicals gradients in environment and the migration toward higher concentration of chemoattractant or lower concentration of repellent. This mechanism is a basic nature of microorganisms to adapt to the environmental changes. The research of microbial chemotaxis is of great significance in utilizing bacteria to solve environment problems, control the pathogen infection, and develop microbial industrial projects. Microfluidic devices can realize qualitatively and quantitatively detect of bacterial chemotaxis. In comparison with traditional detect methods, microfluidic assay has an accurate control over bacterial microenvironment, with a higher sensitivity. In the past few years, bacterial chemotaxis study based on microfluidic assay was developed rapidly. In this paper, the microfluidic chemotaxis detectors that appeared in recent years were introduced from the aspect of chip structure, working principle and their applications. Finally, we provided insights into the challenges of bacterial chemotaxis and provided future perspectives.